Hand cannons can be used in all encounters effectively but aren't your best options.One or two players should consider using a scout rifle in the second, third, fourth, and final encounter due to a handful of long-range enemies.SMGs can be good choices in the second, third, fourth, and sixth encounters as well.Auto rifles and pulse rifles are perfect for the first four encounters, as well as the final two encounters.Here's a full breakdown of what weapons we recommend you keep in your inventory. You'll also need to take down two bosses, and since the DPS phase windows for them aren't huge, you need strong special and heavy weapons that can do a lot of damage quickly. Therefore, you'll want well-rolled primary weapons that come with great PvE perks like ones that boost your reload speed, damage, and ability regen. In the Vault of Glass, you'll be fighting plenty of ads, some of which are a bit tanky.